Brain Volumetric Correlates of Autism Spectrum Disorder Symptoms in Attention Deficit/Hyperactivity Disorder
نویسندگان
چکیده
Autism spectrum disorder (ASD) symptoms frequently occur in subjects with attention deficit/hyperactivity disorder (ADHD). While there is evidence that both ADHD and ASD have differential structural correlates, no study to date has investigated these structural correlates within a framework that robustly accounts for the phenotypic overlap between the two disorders. The presence of ASD symptoms was measured by the parent-reported Children's Social and Behavioural Questionnaire (CSBQ) in ADHD subjects (n = 180), their unaffected siblings (n = 118) and healthy controls (n = 146). ADHD symptoms were assessed by a structured interview (K-SADS-PL) and the Conners' ADHD questionnaires. Whole brain T1-weighted MPRAGE images were acquired and the structural MRI correlates of ASD symptom scores were analysed by modelling ASD symptom scores against white matter (WM) and grey matter (GM) volumes using mixed effects models which controlled for ADHD symptom levels. ASD symptoms were significantly elevated in ADHD subjects relative to both controls and unaffected siblings. ASD scores were predicted by the interaction between WM and GM volumes. Increasing ASD score was associated with greater GM volume. Equivocal results from previous structural studies in ADHD and ASD may be due to the fact that comorbidity has not been taken into account in studies to date. The current findings stress the need to account for issues of ASD comorbidity in ADHD.
منابع مشابه
Relationship between Symptoms of Attention Deficit Hyperactivity Disorder and the Severity of Symptoms in Children with Autism Spectrum Disorder
Background and Objective: Background: The present study investigates the relationship between attention deficit hyperactive disorder (ADHD) and the severity of symptoms in children with autistic spectrum disorder. Methods: The study was conducted on 80 patients with autistic spectrum disorder visiting Child Psychiatric Clinic of Tehran Psychiatric Institute. The severity of autistic sympt...
متن کاملمروری مختصر بر « نقص توجه، کنترل حرکتی و ادراک»
The concept of attention deficit, motion control and perception disorders have been under clinical study for about 20 years in Scandinavia. The symptoms of attention deficit, motion control and perception disorders are diagnosed based on the simultaneous attention deficit disorder/ hyperactivity and growth disorder in children who are not having severe learning disorder or brain paralysis. ...
متن کاملWorking Memory Deficits and its Relationship to Autism Spectrum Disorders
Background: There is a wealth of research done in developed countries on the investigation of the working memory (WM) performance in people with high-functioning Autism Spectrum Disorders (ASD) (IQ>70), with different reported findings. There is a dearth of similar studies in developing countries. In addition, the findings suggest that WM is possibly influenced by culture. The present study inv...
متن کاملMRI Evaluation of the Brain in Children with Attention Deficit and Hyperactivity Disorder; How to Hear the Whispers Early?
Background Attention deficit and hyperactivity disorder (ADHD) is a disorder of the brain characterized by periods of inattention, hyperactivity and impulsive behavior. We aimed to evaluate the role of MRI of the brain in children with ADHD. Materials and Methods This prospective study included 100 children with clinical diagnosis of attention deficit and hyperactivity disorder according to the...
متن کاملThe effectiveness of Dialectical Behavior Therapy on Reducing of Symptoms of Attention Deficit / Hyperactivity and Suicidal Ideation in Symptoms of Attention Deficit / Hyperactivity Disorder Adolescents
Background : Attention Deficit Hyperactivity Disorder means behavioral disorders that begin in childhood and continue into adolescence and even middle age if appropriate therapies are not used. This study aimed to evaluate the effectiveness of dialectical behavior therapy on reducing the symptoms of attention-deficit / hyperactivity disorder and suicidal ideation in adolescents with attention-d...
متن کامل